Clinical Microbiology / Global Health

In collaboration with clinically active colleagues, infectiological issues are investigated depending on the situation. For example, the influence of an antifungal stewardship program on patients suffering from candidemia could be proven. The current therapeutic regimen for toxoplasmosis in pregnancy is based on data from a corresponding study of more than 600 pregnant women. With Corynebacterium goettingense, a new Corynebacterium species was identified and described, which we named after the city of Göttingen. 

In addition, for more than ten years there has been intensive cooperation with partner institutes in
Ghana, Tanzania and Indonesia, which initially aimed tobuild capacitythrough targeted individual training and numerous DAAD-funded summer schools.
The scientific collaboration focuses primarily on epidemiological topics in the areas of gastrointestinal infections, mycoses and pregnancy-related infections.
This work
has shown that the epidemiology of Clostridioides difficile infection appears to be different, particularly in African countries, than in Germany .Our joint investigations have contributed to the regional introduction of pregnancy-related HBV screening in Ghana and vaccination against rubella in Tanzania. It was also shown that vaccination against HPV does not adequately cover the viral genotypes prevalent in Ghana.

Selected Publications:

Blumenröder S, Wilson D, Ndaboine E, Mirambo MM, Mushi MF, Bader O, Zimmermann O, Mshana SE, Groß U. 2023. neonatal infection in sub-Saharan Africa: a cross-sectional pilot study on bacterial pathogens and maternal risk factors. Front Microbiol. 14:1171651. doi: 10.3389/fmicb.2023. 1171651.

Dao V.T-V., A. Anagostou, R. Schlösser, U. Rachwalsky, U. Groß, S. Hoehl, V. A. J. Kempf, S, Besier. 2023. First description of congenital toxoplasmosis after maternal coinfection with Toxoplasma gondii and severe acute respiratory syndrome coronavirus 2: a case report. J Med Case Rep 17: 121. doi: 10.1186/s13256-023-03855-8

Prinz C, Streit F, Schumann C, Dudakova A, Lanckohr C, Schanz J, Bohn M, Groß U, Meissner K, Moerer O, Harnisch LO. 2023. Feasibility of continuous infusion of cefiderocol in conjunction with the establishment of therapeutic drug monitoring in patients with extensively drug-resistant Gram-negative bacteria. Clin Drug Investig. 5:1-8. doi: 10.1007/s40261-023-01257-8

Simanjuntak, D.F., R. L. Kusumawati, O. Bader, C. G. K. Lüder, O. Zimmermann, U. Groß. 2023. A comparative pilot study on Gram-negative bacteria contaminating the hands of children living in urban and rural areas of Indonesia versus Germany - a suitable monitoring strategy for diarrhea risk assessment? Front. Microbiol. 14: 1152411. doi: 10.2289/fmicb.2023.1152411.

Giotaki, I., U. Groß, P. Lange, H.H. Rustenbeck, E. Bahn, R. Nau R. 2022. chronic Candida albicans meningitis misdiagnosed as polymyalgia rheumatica and successfully treated with voriconazole . Clin Case Rep. 10: e05664. doi: 10.1002/ccr3.5664

Dudakova, A., C. Blei, U. Groß, M. H. Schulze. 2022. Impact of routine bedside infectious diseases service on clinical management and prognosis of patients with Candida fungemia - an example for antifungal stewardship at university level in Germany. Int. J. Infct Dis. 119: 150-159. doi: 10.1016/j.ijid.2022.03.054

Hollstein, M.M., L. Münsterkötter, M.P. Schön, A. Bergmann, T. M. Husar, A. Abratis, A. Eidizadeh, S. Dierks, M. Schaffrinski, K. Zachmann, A. Schmitz, J. S. Holsapple, H. Stanisz-Bogeski, J. Schanz, A. Fischer, U. Groß, A. Leha, A. E. Zautner, M. Schnelle, L. Erpenbeck. 2022. Long-term effects of homologous and heterologous SARS-CoV-2 vaccination on humoral and cellular immune responses. Allergy 77: 2560-2564. doi: 10.1111/all.15373

Hollstein, M.M., L. Münsterkötter, M.-P. Schön, A. Bergmann, T. M. Husar, A. Abratis, A. Eidizadeh, M. Schaffrinski, K. Zachmann, A. Schmitz, J. S. Holsapple, H. Stanisz-Bogeski, J. Schanz, A. Fischer, U. Groß, A. Leha, A. E. Zautner, M. Schnelle, L. Erpenbeck. 2022. interdependencies of cellular and humoral immune responses in heterologous and homologous SARS-CoV-2 vaccination, Allergy 77: 2381-2392. doi: 10/1111/all.15247.

Lang, V., K. Gunka, J.R. Ortlepp, O. Zimmermann, U. Groß. 2022. risk factors of patients with diarrhea for having Clostridioides (Clostridium) difficile infection. Front. Microbiol. 13: 840846. doi: 10.3389/fmicb.2022.840846.

Münsterkötter, L., M. M. Hollstein, A. Hahn, A. Kröger, M. Schnelle, L. Erpenbeck, U. Groß, H. Frickmann, A. E. Zautner. 2022. Comparison of the anti-SARS-CoV-2 surrogate neutralization assays by TECOmedical and DiaPROPH-Med with samples from vaccinated and infected individuals. Viruses 14: 315. doi: org/10.3390/v14020315.

Taverne-Ghadwal, L., M. Kuhns, T. Buhl, M. H. Schulze, W. J. Mbaitolum, L. Kersch, M. Weig, O. Bader, U. Groß. 2022. epidemiology and prevalence of oral candidiasis in HIV patients from Chad in the post-HAART era. Front. Microbiol, 13: 844069. doi: 10.3389/fmic.2022.844069.

Zimmermann, O., H. Köchel, W. Bohne, B. Pollok-Kopp, P. Passenberg, U. Groß. 2022. A case report and review of the literature: reactive arthritis caused by Clostridioides difficile ribotype 027. Front. Microbiol. 13: 837422. doi: 10.3389/fmic.2022.837422          

Dierks S, O. Bader, J. Schwanbeck, U. Groß, M. S. Weig, K. Mese, R. Lugert, W. Bohne, A. Hahn, N. Feltgen, S. Torkieh, F. R. Denker, P. Lauermann M. W. Storch, H. Frickmann, A. E. Zautner. 2021. diagnosing SARS-CoV-2 with antigen testing, transcription-mediated amplification and real-time PCR. J. Clin. Med. 10: 2404.

Dörschug A, Frickmann H, Schwanbeck J, Yilmaz E, Mese K, Hahn A, Groß U, Zautner AR. 2021. comparative assessment of sera from individuals after S-gene RNA-based SARS-CoV-2 vaccination with spike protein-based and nucleocapsid-based serological assays. Diagnostics (Basel) 11:426. doi: 10.3390/diagnostics11030426

Dörschug A, Schwanbeck J, Hahn A, Hillebrecht A, Blaschke S, Mese K, Groß U, Dierks S, Frickmann H, Zautner AE. 2021. comparison of five serological assays for the detection of SARS-CoV-2 antibodies. Diagnostics 11: 78. https://doi. org/10.3390/diagnostics11010078

Kunze-Szikszay N, Euler M, Perl T, Kuhns M, Thiess M, Groß U, Quintel M. 2021. headspace analyses using multi-capillary column-ion mobility spectrometry allow rapid pathogen differentiation in hospital-acquired pneumonia relevant bacteria. BMC Microbiology 21:69. doi: 10.1186/s12866-021-02102-8

Monnheimer M, Cooper P, Amegbletor HK, Pellio T, Groß U, Pfeifer Y, Schulze MH. 2021. high revalence of carbapenemase producing Acinetobacter baumannii in wound infections, Ghana 2017/ 2018. microorganisms 9: 537. doi: 10.3390/microorganisms9030537

Wojak KP, Ungermann G, Ichsan I, Gomez-Molero E, Jung K, Weig M, Nauck F, Ziebolz D, Gräser Y, Nau R, Groß U, Alt-Epping B, Bader O. 2021. host age and denture wearing jointly contribute to oral colonization with intrinsically azole-resistant yeasts in the elderly. Microorganisms9:1627. doi: 10.3390/microorganisms9081627

Frentrup, M. Z. Zhou,M. Steglich, J. P. Meier-Kolthoff, M. Göker, T. Riedel, B. Bunk, C. Spröer, J. Overmann, M. Blaschitz, A. Indra, L. von Müller, T.A. Kohl, S. Niemann, C. Seyboldt, F. Klawonn, N. Kumar, T.D. Lawley, S. García-Fernández, R. Cantón, R. del Campo, O. Zimmermann, U. Groß, M. Achtman, U. Nübel. 2020. a publicly accessible database for Clostridioides difficile genome sequences supports tracing of transmission chains and epidemics. Microb. Genomics 6. doi: 10.1099/mgen.0.000410  

Krumkamp R, K. Oppong, B. Hogan, R. Strauss, H. Frickmann, C. Wiafe-Akenten, K. G. Boahen, V. Rickerts, I. McCormick Smith, U. Groß, M. Schulze, A. Jaeger, U. Loderstädt, N. Sarpong, E. Owusu-Dabo, J. May, D. Dekker. 2020. spectrum of antibiotic resistant bacteria and fungi isolated from chronically infected wounds in a rural district hospital in Ghana. PLoS One. 15:e0237263. doi: 10.1371/journal.pone.0237263.

Nißler R, Bader O, Dohmen M, Walter SG, Noll C, Selvaggio G, Groß U, Kruss S. 2020. remote near infrared identification of pathogens with multiplexed nanosensors. Nature Comm. 11:5995. doi: 10.1038/s41467-020-19718-5.

Noll C, Nasruddin-Yekta A, Sternisek P, Weig M, Groß U, Schilling AF, Beil FT, Bader O. Rapid direct detection of pathogens for diagnosis of joint infections by MALDI-TOF MS after liquid enrichment in the BacT/Alert blood culture system . PLoS One 15:e0243790. doi: 10.1371/journal.pone.0243790      

Seugendo M, A. Hokororo, R. Kabyemera, D. R. Msanga, M. M. Mirambo, V. Silago, U. Gross, S . E. Mshana. 2020.High Clostridium difficile Infection among HIV-Infected Children with Diarrhea in a Tertiary Hospital in Mwanza, Tanzania Int J Pediatr 2020:3264923.doi:10.1155/2020/3264923.

Tilkorn FKMT, Frickmann H, Simon IS, Schwanbeck J, Horn S, Zimmermann O, Groß U, Bohne W, Zautner AE. 2020. antimicrobial resistance patterns in Clostridioides difficile strains isolated from neonates in Germany . Antibiotics (Basel) 9:481. doi: 10.3390/antibiotics9080481

Jaka H, Rüttgerodt N, Bohne W, Mueller A, Groß U, Kasang C, Mshana SE. 2019. Helicobacter pylori mutations conferring resistance to fluoroquinolones and clarithromycin among dyspeptic patients attending a tertiary hospital, Tanzania. Can J Gastroenterol Hepatol. 2019:8481375. doi: 10.1155/2019/8481375

Groß U, Brzuszkiewicz E, Gunka K, Starke J, Riedel T, Bunk B, Spröer C, Wetzel D, Poehlein A, Chibani C, Bohne W, Overmann J, Zimmermann O, Daniel R, Liesegang H. 2018. Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infections of C. difficile. BMC Genomics 19:1. doi: 10.1186/s12864-017-4368-0

Idelevich EA, Groß U, Becker K, Bader O. 2018. Comparative evaluation of different gradient diffusion tests for detection of azole resistance in Aspergillus fumigatus. Diagn Microbiol Infect Dis. pii: S0732-8893(18)30007-5. doi: 10.1016/j.diagmicrobio.2018.01.003

Janssen H, Janssen I, Cooper P, Kainyah C, Pellio T, Quintel M, Monnheimer M, Groß U, Schulze MH. 2018. antimicrobial-resistant bacteria in infected wounds, Ghana, 2014. Emerg. Infect. Dis. 24:916-919. doi: 10.3201/eid2405.171506

Mirambo MM, Majigo M, Scana SD, Mushi MF, Aboud S, Groß U, Kidenya BR, Mshana SE. 2018. Rubella natural immunity among adolescent girls in Tanzania: the need to vaccinate child bearing aged women. BMC Womens Health. 18:3. doi: 10.1186/s12905-017-0505-9

Sachsenheimer FE, Yang I, Zimmermann O, Wrede C, Müller LV, Gunka K, Groß U, Suerbaum S. 2018. Genomic and phenotypic diversity of Clostridium difficile during long-term sequential recurrences of infection. Int J Med Microbiol. 308:364-377. doi: 10.1016/j.ijmm.2018.02.002

Seugendo M, Janssen I, Lang V, Hasibuan I, Bohne W, Cooper P, Daniel R, Gunka K, Kusumawati RL, Mshana SE, von Müller L, Okamo B, Ortlepp JR, Overmann J, Riedel T, Rupnik M, Zimmermann O, Groß U. 2018. Prevalence and strain characterization of Clostridioides (Clostridium) difficile in representative regions of Germany, Ghana, Tanzania and Indonesia - a comparative multi-center cross-sectional study. Frontiers Microbiol. 9:1843.

Wilson RM, Moremi N, Mushi MF, Bader O, Ngoya PS, Desderius BM, Rambau P, Kabangila R, Groß U, Mshana SE. 2018. disseminated cryptococcosis in an HIV-negative patient: case report of a newly diagnosed hypertensive adult presenting with hemiparesis. Med Mycol Case Rep. 22:4-7. doi: 10.1016/j.mmcr.2018.07.003

Atasayar E, Zimmermann O, Spröer C, Schumann P, Groß U. 2017. Corynebacterium gottingense sp. nov. isolated from a clinical patient. Int J Syst Evol Microbiol. doi: 10.1099/ijsem.0.002322

Kauffels A, Schmalz G, Kollmar O, Slotta JE, Weig M, Groß U, Bader O, Ziebolz D. 2017. Oral findings and dental behavior before and after liver transplantation - a single-center cross-sectional study. Int Dent J. 67:244-251. doi: 10.1111/idj.12290

Mirambo MM, Aboud S, Groß U, Majigo M, Mushi MF, Mshana SE. 2017. rubella seromarkers and determinants of infection among Tanzanian children and adolescents in prevaccination era: are we in the right track? Int J Prev Med. 8:3. doi: 10.4103/2008-7802.198914

Rößler S, Bader O, Stölzel F, Sommer U, Spiess B, Geibel S, Buchheidt D, Groß U, Baretton G, Jacobs E, Ostrosky-Zeichner L. 2017. Progressive dispersion of azole resistance in Aspergillus fumigatus: fatal invasive aspergillosis in a patient with acute myeloid leukemia infected with an A. fumigatus strain with a cyp51A TR46 Y121F M172I T289 allele. Antimicrob Agents Chemother. 61 pii: e00270-17. doi: 10.1128/AAC.00270-17.

Schneider D, Thürmer A, Gollnow K, Lugert R, Gunka K, Groß U*, Daniel R*. 2017. gut bacterial communities of diarrheic patients with indications of Clostridioides difficile infection. Sci Data. 4:170152. doi: 10.1038/sdata.2017.152

Völker F, Cooper P, Bader O, Uy A, Zimmermann O, Lugert R, Groß U. 2017. prevalence of pregnancy-relevant infections in a rural setting of Ghana. BMC Pregnancy Childbirth. 17:172. doi: 10.1186/s12884-017-1351-3

Janssen I, Cooper P, Gunka K, Rupnik M, Wetzel D, Zimmermann O, Groß U. 2016. High prevalence of nontoxigenic Clostridium difficile isolated from hospitalized and non-hospitalized individuals in rural Ghana. Int J Med Microbiol. 306:652-656. doi: 10.1016/j.ijmm.2016.09.004

Mössner, R., N. Diering, O. Bader, S. Forkel, T. Overbeck, U. Groß, B. Grimbacher, M. P. Schön, and T. Buhl. 2016. ruxolitinib induces interleukin 17 and ameliorates chronic mucocutaneous candidiasis caused by STAT1 gain-of-function mutation. Clin Infect Dis. 62:951-3. doi: 10.1093/cid/ciw020

Schulze MH, Völker FM, Lugert R, Cooper P, Hasenclever K, Groß U, Pfister H, Silling S. 2016. High prevalence of human papillomaviruses in Ghanaian pregnant women. Med Microbiol Immunol. 205:595-602. doi: 10.1007/s00430-016-0475-9

Schwab FD, Zettler EK, Moh A, Schötzau A, Groß U, Günthert AR. 2016. predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh. J Perinat Med. 44: 511-515. doi: 10.1515/jpm-2015-0004

Scholze, K., M. Wenke, R. Schierholz, U. Groß, O. Bader, O. Zimmermann, S. Lemmen, J. R. Ortlepp. 2015. reduction of antibiotic consumption in hospitals. Dt. Ärztebl. 112: 714-721. doi: 10.3238/arztebl.2015.0714

Seugendo M, Mshana SE, Hokororo A, Okamo B, Mirambo MM, von Müller L, Gunka K, Zimmermann O, Groß U. 2015. Clostridium difficile infections among adults and children in Mwanza/Tanzania: is it an underappreciated pathogen among immunocompromised patients in sub-Saharan Africa? New Microbes New Infect. 8:99-102. doi: 10.1016/j.nmni.2015.09.016

Mwambe, B., S. E. Mshana, B. R. Kidenya, A. N. Massinde, H. D. Mazigo, D. Michael, C., and U. Groß. 2013. sero-prevalence and factors associated with Toxoplasma gondii infection among pregnant women attending antenatal care in Mwanza, Tanzania. Parasite Vectors. 6:222. doi: 10.1186/1756-3305-6-222

Hotop, A., H. Hlobil, U. Groß. 2012. efficacy of rapid treatment initiation following primary Toxoplasma gondii infection during pregnancy. Clin. Infect. Dis. 54: 1545-1552. doi: 10.1093/cid/cis234


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